Methotrexate (Oncology-Injection)/Procarbazine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known.
What might happen:
When these two medicines are taken close together, they may reduce your kidney function and decrease the amount of urine that you produce.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. It may be necessary to separate your doses of these medicines by several days. Contact your doctor as soon as possible if you notice a decrease in the amount of urine; bloating; or swelling of the ankles, feet, or hands. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Price P, Thompson H, Bessell EM, Bloom HJ. Renal impairment following the combined use of high-dose methotrexate and procarbazine. Cancer Chemother Pharmacol 1988;21(3):265-7..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.