Trimethoprim-Sulfamethoxazole/Leucovorin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Leucovorin may protect certain bacteria from the effects of your antibiotic.

What might happen:

If you are taking your antibiotic to treat or prevent Pneumocystis jiroveci pneumonia (formerly called Pneumocystis carinii or PCP), it may not work as well.

What you should do about this interaction:

Sometimes these medicines are used together to treat certain side effects of your antibiotic. If you have questions about your medicine, discuss them with your healthcare professionals (e.g. doctor or pharmacist). If you are taking your antibiotic to prevent or treat Pneumocystis jiroveci pneumonia (formerly called Pneumocystis carinii or PCP), let your doctor know right away if your condition does not improve or gets worse.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.