Neratinib/Strong CYP3A4 Inhibitors;Moderate CYP3A4 & P-gp Dual Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Several medicines may slow down how quickly your liver processes neratinib.
What might happen:
The amount of neratinib in your blood may increase and cause side effects.
What you should do about this interaction:
Make sure that your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you experience diarrhea, nausea, vomiting, dizziness, and/or decreased urination.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Nerlynx (neratinib) US prescribing information. Puma Biotechnology, Inc. June, 2021.
- 2.Paxlovid (nirmatrelvir tablets and ritonavir tablets) Canadian Product Monograph. Pfizer Canada ULC December 8, 2022.
- 3.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.