Bortezomib/Strong CYP3A4 Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your other medicine may slow down how quickly your body processes bortezomib.

What might happen:

The amount of bortezomib in your blood may increase and cause more side effects than normal.

What you should do about this interaction:

Make sure that your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Tell your medical provider if you have fever, chills, cough or sore throat, easy bruising or bleeding, tingling or numbness in your hands or feet, persistent nausea, vomiting or diarrhea. Your doctor may want to change your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Velcade (bortezomib) US prescribing information. Mellennium Pharmaceuticals, Inc. October, 2021.
  • 2.Venkatakrishnan K, Rader M, Ramanathan RK, Ramalingam S, Chen E, Riordan W, Trepicchio W, Cooper M, Karol M, von Moltke L, Neuwirth R, Egorin M, Chatta G. Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: a prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study. Clin Ther 2009;31 Pt 2:2444-58.
  • 3.Iwamoto T, Ishibashi M, Fujieda A, Masuya M, Katayama N, Okuda M. Drug interaction between itraconazole and bortezomib: exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib. Pharmacotherapy 2010 Jul;30(7):661-5.
  • 4.Koda Y, Mori T, Shimizu T, Kato J, Yamane A, Sadahira K, Tsukada Y, Yokoyama K, Hashimoto N, Hattori Y, Okamoto S. Early onset of paralytic ileus caused by simultaneous administration of bortezomib and azole antifungals in multiple myeloma patients. Rinsho Ketsueki 2012 Aug; 53(8):760-4.
  • 5.Hashimoto N, Yokoyama K, Sadahira K, Ueda T, Tsukada Y, Okamoto S. Itraconazole may increase the risk of early-onset bortezomib-induced peripheral neuropathy. Int J Hematol 2012 Dec;96(6):758-63.
  • 6.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.