Chenodiol/Aluminum-Based Antacids; Bile Acid Sequestrants Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

If your cholesterol medicine or antacid is taken too close to the time of your dose of chenodiol, it may bind to the chenodiol in your digestive tract, preventing your body from absorbing the chenodiol.

What might happen:

A decrease in the beneficial effects of your chenodiol may occur.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking both of these medicines.If you must take aluminum-based antacids or colestipol, take your chenodiol at least 2 hours before or 2 hours after the antacid or colestipol.If you must take cholestyramine, take your chenodiol at least 1 hour before or at least four to six hours after cholestyramine.If you have questions about how to time your medicines, ask your pharmacist.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Chenodol (chenodiol) US prescribing information. Retrophin, Inc. June, 2020.
  • 2.Chenodeoxycholic Acid Leadiant EMA Summary of Product Characteristics. Leadiant GmbH November 24, 2017.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.