Selected Anticonvulsants; Barbiturates/Slt Azole Antifungals Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Fluconazole, itraconazole, and ketoconazole may slow down how quickly your liver processes your seizure medicine.Your seizure medicine may speed up how quickly your liver processes itraconazole and ketoconazole.
What might happen:
If you take fluconazole, itraconazole, or ketoconazole with your seizure medicine, the amount of seizure medicine in your blood may increase and may cause toxic side effects such as drowsiness, dizziness, blurred or double vision, or loss of coordination.If you take your seizure medicine with your itraconazole or ketoconazole, the amount of itraconazole or ketoconazole in your blood may decrease and it may not work as well.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.If you are taking fluconazole, itraconazole or ketoconazole, your doctor may want to check the amount of seizure medicine in your blood during and after treatment with your antifungal medicine. Your doctor may need to change the dose of your seizure medicine during and after your treatment with fluconazole, itraconazole, or ketoconazole. Let your doctor know right away if you have any symptoms of seizure medicine toxicity.If you are taking itraconazole or ketoconazole, let your doctor know if your condition does not improve or worsens. Your doctor may need to change your antifungal medicine.If you are unsure which antifungal agent you are taking, ask your healthcare professional.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.