Selected Corticosteroids/Levoketoconazole Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Levoketoconazole may slow down how quickly your body processes your corticosteroid.
What might happen:
The levels of corticosteroid in your blood may increase.
What you should do about this interaction:
Tell your healthcare professional (e.g. doctor or pharmacist) that you are taking both of these medicines. Your doctor may wish to change the dose of your medicine or change your medicine. Let your doctor know right away if you notice any swelling of your face, neck, or trunk; pain in the abdomen or back, prolonged sore throat or fever, or mood changes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Main KM, Skov M, Sillesen IB, Dige-Petersen H, Muller J, Koch C, Lanng S. Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient. Acta Paediatr 2002;91(9):1008-11.
- 2.De Wachter E, Malfroot A, De Schutter I, Vanbesien J, De Schepper J. Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450. J Cyst Fibros 2003 Jun; 2(2):72-5.
- 3.Seidegard J. Reduction of the inhibitory effect of ketoconazole on budesonide pharmacokinetics by separation of their time of administration. Clin Pharmacol Ther 2000 Jul;68(1):13-7.
- 4.Woods DR, Arun CS, Corris PA, Perros P. Cushing's syndrome without excess cortisol. BMJ 2006 Feb 25;332(7539):469-70.
- 5.Glynn AM, Slaughter RL, Brass C, D'Ambrosio R, Jusko WJ. Effects of ketoconazole on methylprednisolone pharmacokinetics and cortisol secretion. Clin Pharmacol Ther 1986 Jun;39(6):654-9.
- 6.Kandrotas RJ, Slaughter RL, Brass C, Jusko WJ. Ketoconazole effects on methylprednisolone disposition and their joint suppression of endogenous cortisol. Clin Pharmacol Ther 1987 Oct;42(4):465-70.
- 7.Yamashita SK, Ludwig EA, Middleton E Jr, Jusko WJ. Lack of pharmacokinetic and pharmacodynamic interactions between ketoconazole and prednisolone. Clin Pharmacol Ther 1991 May;49(5):558-70.
- 8.Omnaris (ciclesonide) US prescribing information. Nycomed US Inc. November 20, 2007.
- 9.Dulera (mometasone furoate/formoterol) US prescribing information. Merck & Co., Inc. August, 2019.
- 10.Kempsford R, Allen A, Bal J, Rubin D, Tombs L. The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of inhaled fluticasone furoate and vilanterol trifenatate in healthy subjects. Br J Clin Pharmacol 2013 Jun;75(6):1478-87.
- 11.Flovent Diskus (fluticasone propionate) US prescribing information. GlaxoSmithKline January, 2019.
- 12.Recorlev (levoketoconazole) US prescribing information. Xeris Pharmaceuticals, Inc. June, 2023.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.