Selected Steroids/Nirmatrelvir-Ritonavir Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nirmatrelvir-ritonavir may slow down how quickly your liver processes certain corticosteroids.
What might happen:
The amount of corticosteroid in your blood may increase and cause side effects.
What you should do about this interaction:
Make sure that your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medications together. Let your doctor know right away if you notice any swelling of your face, neck, or trunk; pain in abdomen or back, prolonged sore throat or fever, or mood changes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Paxlovid (nirmatrelvir tablets and ritonavir tablets) US prescribing information. Pfizer Inc. May, 2023.
- 2.Norvir (ritonavir) US prescribing information. Abbott Laboratories December, 2019.
- 3.Flovent HFA inhalation (fluticasone propionate) US prescribing information. GlaxoSmithKline January, 2019.
- 4.Flovent Rotadisk (fluticasone propionate) US prescribing information. GlaxoSmithKline March, 2004.
- 5.Flonase Nasal Spray (fluticasone propionate) US prescribing information. GlaxoSmithKline January, 2019.
- 6.Flovent Diskus (fluticasone propionate) US prescribing information. GlaxoSmithKline January, 2019.
- 7.Penzak SR, Formentini E, Alfaro RM, Long M, Natarajan V, Kovacs J. Prednisolone pharmacokinetics in the presence and absence of ritonavir after oral prednisone administration to healthy volunteers. J Acquir Immune Defic Syndr 2005 Dec 15;40(5):573-80.
- 8.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.