Disopyramide/Ombitasvir-paritaprevir-ritonavir Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your hepatitis C medicine (ombitasvir-paritaprevir-ritonavir) may slow down how fast your body processes your disopyramide.
What might happen:
Your blood levels of disopyramide may increase and cause side effects including potentially life-threatening changes to your heart rhythm.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know you are taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it.If you experience an irregular heartbeat/palpitations, feel dizzy, or have fainting episodes, contact your doctor as soon as possible. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Viekira Pak (ombitasvir, paritaprevir, and ritonavir; dasabuvir) US prescribing information. AbbVie Inc. December, 2019.
- 2.Echizen H, Tanizaki M, Tatsuno J, Chiba K, Berwick T, Tani M, Gonzalez FJ, Ishizaki T. Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans. Drug Metab Dispos 2000 Aug;28(8):937-44.
- 3.Norpace (disopyramide phosphate) US prescribing information. Pfizer Inc. December, 2020.
- 4.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.