Selected Azole Antifungal CYP3A4 Substrates/Enasidenib Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Enasidenib may speed up how quickly your body processes your antifungal medicine.
What might happen:
The anti-infective effects of your antifungal medicine may decrease.
What you should do about this interaction:
If signs of your infection do not improve or worsen, contact your doctor. It may be necessary to adjust the dose of your medicines or to change your medicines.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.
- 1.Idhifa (enasidenib) US prescribing information. Celgene Corporation November, 2020.
- 2.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. February, 2024.
- 3.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
- 4.Diflucan (fluconazole) US prescribing information. Pfizer Inc. January, 2023.
- 5.Cresemba (isavuconazonium sulfate) US prescribing information. Astellas Pharma US, Inc. May, 2021.
- 6.Noxafil (posaconazole) US prescribing information. Merck & Co. Inc January, 2022.
- 7.Vfend (voriconazole) US prescribing information. Pfizer Inc. October, 2022.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.