Ethyl Alcohol/Levoketoconazole; Ketoconazole Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Levoketoconazole and ketoconazole can cause an intolerance to alcohol. Many medicines (prescription and nonprescription), mouthwashes, and aftershaves contain alcohol. Even a small amount of alcohol (e.g. 15 ml or one tablespoon) can trigger the effects.
What might happen:
Ingesting alcohol or using topical preparations that contain alcohol may result in throbbing in the head and neck, irregular heart beat, rapid heart beat, low blood pressure, sweating, flushing, nausea, and vomiting. Symptoms generally last for a few hours.
What you should do about this interaction:
Avoid excessive consumption of alcoholic beverages and products containing alcohol while you are taking levoketoconazole or ketoconazole. If possible, avoid the use of medicines that contain alcohol when using levoketoconazole or ketoconazole. Use of topical products such as creams or lotions that contain alcohol may also cause this interaction. The amount of alcohol required to cause this interaction varies with individuals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Fazio RA, Wickremesinghe PC, Arsura EL. Ketoconazole treatment of Candida esophagitis--a prospective study of 12 cases. Am J Gastroenterol 1983 May; 78(5):261-4.
- 2.Recorlev (levoketoconazole) US prescribing information. Xeris Pharmaceuticals, Inc. June, 2023.
- 3.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
- 4.USFood and Drug Administration (FDA). Docetaxel: Drug Safety Communication - May Cause Symptoms of Alcohol Intoxication. available at: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-com munication-fda-warns-cancer-drug-docetaxel-may-cause-symptoms-alcohol June 20, 2014.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.