Pimozide/Selected Azole Antifungals Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When pimozide is taken with some antifungal medicines, your body may process pimozide more slowly.
What might happen:
Your blood levels of pimozide may increase. This may result in an irregular heartbeat, which may be life threatening.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.
- 1.Diflucan (fluconazole) US prescribing information. Pfizer Inc. January, 2023.
- 2.Orap (pimozide) US prescribing information. Gate Pharmaceuticals August, 2011.
- 3.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. February, 2024.
- 4.Noxafil (posaconazole) UK summary of product characteristics. Schering-Plough Ltd. January, 2022.
- 5.Noxafil (posaconazole) US prescribing information. Merck & Co. Inc January, 2022.
- 6.Vfend (voriconazole) US prescribing information. Pfizer Inc. October, 2022.
- 7.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
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- 9.American Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2023 Jul;71(7):2052-2081.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.