Colchicine/Fibrates Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of these medicines can cause muscle damage.

What might happen:

Using these medicine together may damage your muscles.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Make sure your doctor knows if you have any kidney problems, which may make the interaction worse. Your doctor may need to change your medicine or the dose of your colchicine.Let your doctor know right away if you have any unexpected muscle pain, tenderness or weakness; unexplained tiredness; discolored urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Colcrys (colchicine) US prescribing information. AR Scientific, Inc. July, 2011.
  • 2.Lopid (gemfibrozil) US prescribing information. Pfizer Pharmaceuticals, Ltd. December, 2020.
  • 3.Atmaca H, Sayarlioglu H, Kulah E, Demircan N, Akpolat T. Rhabdomyolysis associated with gemfibrozil-colchicine therapy. Ann Pharmacother 2002 Nov; 36(11):1719-21.
  • 4.Sugie M, Kuriki A, Arai D, Ichikawa H, Kawamura M. A case report of acute neuromyopathy induced by concomitant use of colchicine and bezafibrate. No To Shinkei 2005 Sep;57(9):785-90.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.