Cyclosporine/Selected Fibrates Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, the potential toxic effects on your kidney may be increased.

What might happen:

Taking these medicines together may increase the risk of damage to your kidneys.

What you should do about this interaction:

If your doctor prescribes these medicines together, you may need to have kidney tests more frequently. Be sure to keep all laboratory appointments and let your doctor know if you notice a change in amount of urine you are making.Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Neoral (cyclosporine) US prescribing information. Novartis Pharmaceuticals Corporation September, 2023.
  • 2.deLorgeril M, Boissonnat P, Bizollon CA, Guidollet J, Faucon G, Guichard JP, Levy-Prades-Sauron R, Renaud S, Dureau G. Pharmacokinetics of cyclosporine in hyperlipidaemic long-term survivors of heart transplantation. Lack of interaction with the lipid-lowering agent, fenofibrate. Eur J Clin Pharmacol 1992;43(2):161-5.
  • 3.Hanes DS, Nicholson PG, Raval DD, Hooper FL, Behrens MT, Weir MR. A crossover comparison of the efficacy and safety of lovastatin and gemfibrozil in the treatment of hyperlipidemic organ transplant recipients. Am J Ther 1997 Feb-Mar;4(2-3):85-91.
  • 4.Broeders N, Knoop C, Antoine M, Tielemans C, Abramowicz D. Fibrate-induced increase in blood urea and creatinine: is gemfibrozil the only innocuous agent?. Nephrol Dial Transplant 2000 Dec;15(12):1993-9.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.