Who should not take Lexapro?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • seizures
  • liver problems
  • heart attack within the last 30 days
  • closed angle glaucoma
  • serotonin syndrome
  • a type of disorder with high serotonin levels
  • a form of mania that has a lower severity of symptoms
  • an increased risk of bleeding
  • a disorder with excess antidiuretic hormone called syndrome of inappropriate antidiuretic hormone
  • low amount of magnesium in the blood
  • neuroleptic malignant syndrome
  • a reaction characterized by fever
  • muscle rigidity and confusion
  • torsades de pointes
  • a type of abnormal heart rhythm
  • prolonged QT interval on EKG
  • abnormal EKG with QT changes from birth
  • bleeding from stomach
  • esophagus or duodenum
  • low amount of potassium in the blood
  • suicidal thoughts
  • CYP2C19 ultrarapid metabolizer
  • risk of angle-closure glaucoma due to narrow angle of anterior chamber of eye
  • CYP2C19 poor metabolizer
  • manic-depression
  • manic behavior
  • low amount of sodium in the blood
  • chronic kidney disease stage 4 (severe)


  • SSRI's
  • Citalopram Analogues

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.