Citalopram; Escitalopram/Slt Dual CYP2C19 & CYP3A4 Inducers Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your other medicine may change how your liver processes your antidepressant medicine.

What might happen:

The amount of your antidepressant medicine in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

View Reference
  • 1.Celexa (citalopram hydrobromide) US prescribing information. Forest Laboratories Inc. August, 2023.
  • 2.Lexapro (escitalopram oxalate) US prescribing information. Forest Pharmaceuticals Inc. September, 2021.
  • 3.Steinacher L, Vandel P, Zullino DF, Eap CB, Brawand-Amey M, Baumann P. Carbamazepine augmentation in depressive patients non-responding to citalopram: a pharmacokinetic and clinical pilot study. Eur. Neuropsychopharmacol. September 2001.;12:255-260.
  • 4.Kukoyi O, Argo TR, Carnahan RM. Exacerbation of panic disorder with rifampin therapy in a patient receiving citalopram. Pharmacotherapy 2005; 25(3):435-437.
  • 5.Leinonen E, Lepola U, Koponen H. Substituting carbamazepine with oxcarbazepine increases citalopram levels: a report on two cases. Pharmacopsychiat. 1996;29:156-158.
  • 6.Khalili H, Dashti-Khavidaki S, Amini S, Mousavi M. Recurrence of panic attacks after brucellosis treatment--highly probable citalopram and rifampin drug interaction. J. Clin. Psychopharmacol. December 2012; 32(6):842-844.
  • 7.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
  • 8.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.