Selected Inhalation Anesthetic Agents/Sympathomimetics Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Sympathomimetics can increase blood pressure and heart rate, which can increase the ability of anesthetics to change the rhythm of the heart.

What might happen:

You may develop an irregular heartbeat.

What you should do about this interaction:

These medicines are used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Weiner N. Norepinephrine, epinephrine, and the sympathomimetic amines. In Gilman AG, Goodman LS, Rall TW, Murad F, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: MacMillan Publishing Company. 1985.
  • 2.Concerta (methylphenidate) Extended-Release prescribing information. Janssen Pharmaceuticals October, 2023.
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  • 13.Ikezono E, Yasuda K, Hattori Y. Effects of propranolol on epinephrine-induced arrhythmias during halothane anesthesia in man and cats. Anesth Analg 1969 Jul-Aug;48(4):598-604.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.