Selected ACE Inhibitors/Potassium Supplements Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process potassium properly.

What might happen:

Your blood levels of potassium may increase and cause toxic effects.

What you should do about this interaction:

If you experience breathing difficulties, chest pain, irregular heartbeat, confusion, or muscle weakness, contact your doctor. If your doctor prescribes these two medicines together, you may need to check your blood level of potassium. The dose of your medicines may need adjusting. This interaction may be worse if you have kidney disease or diabetes.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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  • 2.Grossman A, Eckland D, Price P, Edwards CR. Captopril: reversible renal failure with severe hyperkalaemia. Lancet 1980 Mar 29;1(8170):712.
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  • 8.Papadimitriou M, Zamboulis C, Alexopoulos E, Liamos H, Sakellariou G, Memmos D, Metaxas P, Thessaloniki G. Alarming hyperkalemia during captopril administration in patients on regular hemodialysis. Dialysis Transplant 1985 Aug;14:473-5.
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  • 10.Cozaar (losartan potassium) US prescribing information. Merck & Co., Inc. October, 2021.
  • 11.Diovan (valsartan) US prescribing information. Novartis Pharmaceuticals Corporation June, 2019.
  • 12.Tekturna (aliskiren) US prescribing information. Novartis Pharmaceuticals Corporation November, 2017.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.