Who should not take Norpramin?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • schizophrenia
  • suicidal thoughts
  • serotonin syndrome
  • a type of disorder with high serotonin levels
  • heart attack within the last 30 days
  • torsades de pointes
  • a type of abnormal heart rhythm
  • abnormal heart rhythm
  • abnormal EKG with QT changes from birth
  • liver problems
  • overactive thyroid gland
  • manic-depression
  • a low seizure threshold
  • closed angle glaucoma
  • prolonged QT interval on EKG
  • a stroke
  • enlarged prostate
  • an inability to completely empty the bladder
  • decreased kidney function
  • seizures
  • CYP2D6 poor metabolizer
  • risk of angle-closure glaucoma due to narrow angle of anterior chamber of eye
  • alcohol use disorder
  • coronary artery disease


  • Tricyclic Antidepressants and Tricyclic Compounds

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.