Daprodustat/Strong CYP2C8 Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Gemfibrozil slows down how quickly your liver processes daprodustat.
What might happen:
The amount of daprodustat in your blood may increase and you may be at a higher risk for high blood pressure, blood clots in your arteries, veins and lungs, heart attack, and stroke when taking these two medicines together.
What you should do about this interaction:
Make sure healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your other medicine while you are taking daprodustat.Seek medical care immediately if you experience chest pain; shortness of breath; pain in your arms, neck, jaw or back; swelling, pain, or tenderness in your legs; sudden numbness or weakness, especially on one side of the body; headache or confusion; or problems with vision, speech, or balance.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Jesduvroq (daprodustat) US Prescribing Information. GlaxoSmithKline Feb, 2023.
- 2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
- 3.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.