Live Typhoid Vaccine/Antimicrobials Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, the antimicrobial may cause the live vaccine to not work as well.

What might happen:

The effects of your antimicrobial may make the vaccine ineffective.

What you should do about this interaction:

Before receiving a vaccination, let your doctor know if you are taking any antimicrobials.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Typhoid Vaccine Live Oral Ty 21a US prescribing information. Berna Products Corp. 1997.
  • 2.Centers for Disease Control and Prevention. General Recommendations on Immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. Available at: February 17, 2022;60(RR No.
  • 3):1-68.
  • 4.Center for Disease Control and Prevention. Updated Recommendations for the Use of Typhoid Vaccine - Advisory Committee on Immunization Practices, United States, 2015. MMWR. Available at: March 27, 2015; 64(11):1-24.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.