Esomeprazole; Omeprazole/Select CYP2C19 and CYP3A4 Inducer Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may speed up how quickly your liver processes your proton pump inhibitor.
What might happen:
The amount of proton pump inhibitor in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Contact your healthcare provider if your proton pump inhibitor does not seem to be working as well for your stomach condition.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Nexium (esomeprazole magnesium) US prescribing information. AstraZeneca Pharmaceuticals LP August, 2021.
- 2.Prilosec (omeprazole) US prescribing information. AstraZeneca Pharmaceuticals LP June, 2018.
- 3.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
- 4.Xtandi (enzalutamide) US prescribing information. Astellas Pharma US, Inc. September, 2022.
- 5.Erleada (apalutamide) US prescribing information. Janssen Biotech, Inc. July, 2021.
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- 8.Xie HG. Additional discussions regarding the altered metabolism and transport of omeprazole after long-term use of St John's wort. Clin Pharmacol Ther 2005 Oct;78(4):440-1.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.