Mavacamten/Strong & Moderate CYP2C19 Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your medicine may slow down how quickly your body processes mavacamten.

What might happen:

The amount of mavacamten in your body may increase and cause increased side effects. You may have an increased risk of developing heart failure. Signs to be aware of include feeling tired, chest pain, swelling in your legs, unexpected weight gain, shortness of breath or increased heart rate.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your mavacamten. Let your doctor know right away if you have any signs or problems associated with heart failure.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Camzyos (mavacamten) US prescribing information. Bristol-Myers Squibb April, 2024.
  • 2.Camzyos (mavacamten) Canadian product monograph. Bristol-Myers Squibb Canada February, 2024.
  • 3.Camzyos (mavacamten) UK Summary of Product Characteristics. Bristol-Myers Squibb July, 2023.
  • 4.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
  • 5.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.