Digoxin/Propafenone;Flecainide Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known. Propafenone or flecainide may increase the effects of your digoxin.

What might happen:

The blood levels of your digoxin may increase and cause nausea, vomiting, or a slow or irregular heartbeat.

What you should do about this interaction:

If you experience nausea, vomiting, or a slow or irregular heartbeat, contact your healthcare professional (e.g. doctor or pharmacist.) You may need to have your digoxin level checked and your doctor may want to adjust the dose of your medicine.Your healthcare professionals may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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  • 14.Lanoxin (digoxin) Tablets US prescribing information. Covis Pharmaceuticals, Inc. August, 2018.
  • 15.Lanoxin Injection (digoxin) US prescribing information. Covis Pharma October, 2019.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.