Clozapine/Givosiran Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Givosiran may slow the breakdown of clozapine by your liver.
What might happen:
If the blood level of clozapine increases, you may have an increase in side effects. You may experience a fast heartbeat, low blood pressure, fatigue, dizziness, increased salivation, seizures or decreased breathing.
What you should do about this interaction:
Contact your healthcare professionals (e.g doctor or pharmacist) about taking these medications together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Givlaari (givosiran) US prescribing information. Alnylam Pharmaceuticals, Inc. October, 2021.
- 2.Vassiliou D, Sardh E, Harper P, Najafian N, Simon A, Burke A, Kim J, Garg P, Robbie G, Agarwal S. A Drug-Drug Interaction Study to Investigate the Effect of Givosiran on the activity of 5 major drug metabolizing CYP450 enzymes in Subjects with Acute Intermittent Porphyria (AIP) who are Chronic High Excreters (CHE). International Congress on Porphyrins and Porphyrias, Milan Italy September 10, 2019.
- 3.Clozaril (clozapine tablets) US prescribing information. Novartis Pharmaceuticals Corporation April, 2020.
- 4.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.