Clozapine/Osilodrostat Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Clozapine can affect your heart's rhythm and your bone marrow's ability to make new white blood cells. Osilodrostat can have the same effect on your heart and can slow down how quickly your body processes clozapine.
What might happen:
Taking clozapine with osilodrostat may increase your risk of side effects including low white blood cell counts and irregular heartbeat, which may be life-threatening. If your white blood cells are too low (also called the ANC or absolute neutrophil count), your risk for infection is increased.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and all other medicines you are taking. Your doctor may want to perform an electrocardiogram (ECG) on you to check your heart rate and rhythm. Your doctor may want to check your blood frequently to be sure your white blood cells are in a safe range. It is important to keep laboratory appointments.Let your doctor know right away if you notice any irregular heartbeat or have any dizziness or fainting episodes. You should contact your healthcare provider right away if you have symptoms of infection such as fever, sore throat or flu-like symptoms.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Isturisa (osilodrostat) US prescribing information. Recordati Rare Diseases, Inc. March, 2020.
- 2.Clozaril (clozapine tablets) US prescribing information. Novartis Pharmaceuticals Corporation April, 2020.
- 3.FDA (US Food and Drug Administration). Clozapine: Drug Safety Communication - FDA Modifies Monitoring for Neutropenia; Approves New Shared REMS Program. accessed at: http://www.fda.gov/drugs/drugsafety/ucm461853.htm September 15, 2015.
- 4.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.