Live Vaccines; Live BCG/Teplizumab Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Teplizumab may suppress your immune system and prevent your body from responding correctly to vaccines and BCG medicines used for bladder cancer.
What might happen:
If you received a live vaccine within 8 weeks before you receive teplizumab, or you receive a live vaccine during or within 52 weeks after you stop teplizumab therapy, you may not develop disease immunity from your vaccine. The live vaccine may cause you to develop the illness it was supposed to prevent. If a non-live, or inactive, version of your vaccine is available, it may be an option for you because inactive vaccines cannot cause you to develop the illness it was supposed to prevent, even if you receive immunosuppressant medicine.If you received your BCG bladder medicine within 8 weeks before you receive teplizumab, or you receive the BCG bladder medicine during or within 52 weeks after you stop teplizumab therapy, the BCG bladder medicine may not work as well. You may get a severe infection if the BCG medicine gets into your blood stream.
What you should do about this interaction:
Before receiving a live vaccine or BCG medicine for bladder cancer, let your doctor know all of the other medicines you are taking. Your doctor may decide to give you an inactive vaccine, change the timing of your vaccination, or change when you receive your BCG bladder medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Centers for Disease Control and Prevention. General Recommendations on Immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. Available at: https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/index.html February 17, 2022;60(RR No.
- 2):1-68.
- 3.Tzield (teplizumab-mzwv) US prescribing information. Provention Bio, Inc. November, 2022.
- 4.TICE BCG (BCG live, for intravesical use) prescribing information. Organon USA Inc. October, 2010.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.