Selected HMG-CoA Reductase Inhibitors/Digoxin Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
How this interaction occurs is not known.
What might happen:
Digoxin may increase the amount of your cholesterol medicine in your blood, which can cause muscle problems.Some cholesterol medicines (atorvastatin and simvastatin) may increase the amount of digoxin in your blood and cause side effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have any unexplained muscle aches, tenderness, weakness, flu-like symptoms, or have dark colored urine.If you are taking atorvastatin or simvastatin, your doctor may want to check the amount of digoxin in your blood and change the dose of your digoxin. Let your doctor know if you have any nausea, vomiting, headaches, fatigue, drowsiness, weakness, disorientation, hallucinations, changes in vision, or a slow/irregular heartbeat.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Bellosta S, Paoletti R, Corsini A. Safety of statins: focus on clinical pharmacokinetics and drug interactions. Circulation 2004 Jun 15;109(23 Suppl 1):III50-7.
- 2.Lipitor (atorvastatin) US prescribing information. Pfizer Inc. November, 2020.
- 3.Zocor (simvastatin) US prescribing information. Merck & Co., Inc. March, 2023.
- 4.Lanoxin (digoxin) Tablets US prescribing information. Covis Pharmaceuticals, Inc. August, 2018.
- 5.Omar MA, Wilson JP. FDA adverse event reports on statin-associated rhabdomyolysis. Ann Pharmacother 2002 Feb;36(2):288-95.
- 6.Lescol (fluvastatin sodium) US prescribing information. Novartis Pharmaceuticals Corporation August, 2017.
- 7.Mevacor (lovastatin) US prescribing information. Merck & Co., Inc. February, 2014.
- 8.Pravachol (pravastatin sodium) US prescribing information. Bristol-Myers Squibb Company May, 2022.
- 9.Crestor (rosuvastatin calcium) US prescribing information. AstraZeneca Pharmaceuticals LP July, 2023.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.