Atorvastatin; Lovastatin; Simvastatin/Glecaprevir-Pibrentasvir Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Glecaprevir-pibrentasvir may increase the amount of cholesterol medicine your body absorbs.

What might happen:

You may experience muscle aches, tenderness, or weakness.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want to change the dose of your cholesterol medicine or you may need to take a different cholesterol medicine.Tell your doctor right away if you experience muscle pain, tenderness, or weakness; unexplained tiredness; or discolored urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Mavyret (glecaprevir and pibrentasvir) US prescribing information. AbbVie Inc. October, 2023.
  • 2.Maviret (glecaprevir and pibrentasvir) UK Summary of Product Characteristics. AbbVie Ltd. August, 2021.
  • 3.Maviret (glecaprevir and pibrentasvir) CA prescribing information. AbbVie Corporation November 28, 2018.
  • 4.Lipitor (atorvastatin) US prescribing information. Pfizer Inc. November, 2020.
  • 5.Lipitor (atorvastatin) Canadian product information. Pfizer Canada Inc. May 31, 2019.
  • 6.Lipitor (atorvastatin calcium trihydrate) UK summary of product characteristics. Pfizer Limited April 1, 2019.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.