Lithium/Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Sodium-glucose cotransporter 2 (SGLT2) inhibitors may cause your kidneys to remove lithium from your blood more quickly.
What might happen:
The amount of lithium in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check the amount of lithium in your blood. Let your doctor know if you do not think that your lithium is working.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Armstrong GP. Empagliflozin-Mediated Lithium Excretion: A Case Study and Clinical Applications. Am J Case Rep 2020 Jun 10;21:e923311.
- 2.Eickhoff MK, Dekkers CCJ, Kramers BJ, Laverman GD, Frimodt-Moller M, Jorgensen NR, Faber J, Danser AHJ, Gansevoort RT, Rossing P, Persson F, Heerspink HJL. Effects of Dapagliflozin on Volume Status When Added to Renin-Angiotensin System Inhibitors. J Clin Med 2019 May 31;8(6):.
- 3.Steglatro (ertugliflozin) US prescribing information. Merck & Co. October 2022.
- 4.Jardiance (empagliflozin) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. June, 2023.
- 5.Invokana (canagliflozin) US prescribing information. Janssen Pharmaceuticals, Inc. October, 2022.
- 6.Lithobid (lithium carbonate) US prescribing information. ANI Pharmaceuticals, Inc. May, 2018.
- 7.Horowitz LC, Fisher GU. Acute lithium toxicity. N Engl J Med 1969 Dec 11; 281(24):1369.
- 8.Thomsen K, Schou M. Renal lithium excretion in man. Am J Physiol 1968 Oct; 215(4):823-7.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.