Clofarabine/Trilaciclib Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Trilaciclib may inhibit the ability of your kidneys to remove clofarabine from your body.
What might happen:
The amount of clofarabine in your body may increase and cause more side effects than expected, including infections, bleeding, kidney damage and liver damage.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of clofarabine or change you to a different medicine. Let your doctor or pharmacist know if you develop any new side effects of your medication, including nausea, vomiting, severe diarrhea, loss of appetite, decreased urination, dark urine, yellowing of your eyes, fever, infections, unusual bleeding or bruising, or rash.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Cosela (trilaciclib) US prescribing information. G1 Therapeutics, Inc. February, 2021.
- 2.Clolar (clofarabine) US prescribing information. Sanofi-Aventis U.S. LLC October 15, 2020.
- 3.Ajavon AD, Bonate PL, Taft DR. Renal excretion of clofarabine: assessment of dose-linearity and role of renal transport systems on drug excretion. Eur J Pharm Sci 2010 Jun 14;40(3):209-16.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.