Cyclosporine/Tigecycline Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
How this interaction occurs is not known.
What might happen:
The amount of cyclosporine in your blood may increase. If the levels of cyclosporine in your blood are too high, it may damage your kidneys.
What you should do about this interaction:
Make sure that your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check the amount of cyclosporine in your blood and your kidney function more often while you are taking your antibiotic.Tell your doctor if you experience any shortness of breath, unusual swelling, changes in the color or amount of your urine, or changes in how often you urinate, contact your doctor.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Srinivas NR. Tigecycline and cyclosporine interaction-an interesting case of biliary-excreted drug enhancing the oral bioavailability of cyclosporine. Eur J Clin Pharmacol 2009 May;65(5):543-4.
- 2.Tygacil (tigecycline) Canadian prescribing information. Pfizer Canada ULC April 21, 2020.
- 3.Tygacil (tigecycline) UK summary of product characteristics. Pfizer Limited April 26, 2021.
- 4.Stumpf AN, Schmidt C, Hiddemann W, Gerbitz A. High serum concentrations of cyclosporin related to administration of tigecycline. Eur J Clin Pharmacol 2009 Jan;65(1):101-3.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.