Dolutegravir/Selected Oral Cations Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your medicine contains aluminum, calcium, iron, lanthanum, magnesium, sucralfate, and/or zinc, which are cations that may bind to your dolutegravir in your digestive tract. This prevents your body from absorbing dolutegravir.

What might happen:

The blood levels of your dolutegravir may be decreased, which will decrease its effectiveness.

What you should do about this interaction:

You should time when you take your dolutegravir and your other medicine so that you do take dolutegravir either 2 hours before or 6 hours after your other medicine. If you have questions about how to time when you take your medicines, ask your pharmacist.

  • 1.Tivicay (dolutegravir) US prescribing information. GlaxoSmithKline October, 2022..

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.