Topical Collagenase; Papain/Topical Heavy Metals Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Heavy metals, such as lead, mercury, and silver, which are contained in some antiseptics and other topical products, may inactivate collagenase and papain.
What might happen:
Your collagenase or papain may not work as well in treating your wound.
What you should do about this interaction:
Avoid applying products that contain lead, mercury, or silver to the same wound area to which you are applying collagenase or papain. If you have any questions, contact your healthcare professional (e.g. doctor or pharmacist).Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Santyl (collagenase) US prescribing information. Ross Products Division, Abbott Laboratories, Inc. December, 2003.
- 2.Accuzyme (papain, urea) ointment US prescribing information. Healthpoint, Ltd. November, 2004.
- 3.Accuzyme (papain, urea) spray US prescribing information. Healthpoint, Ltd. March, 2004.
- 4.Ethezyme, Ethezyme 830 (papain, urea) ointment US prescribing information. Ethex Corporation July, 2004.
- 5.Gladase (papain, urea) ointment US prescribing information. Smith & Nephew, Inc. March, 2005.
- 6.Gladase-C (papain, urea) ointment US prescribing information. Smith & Nephew, Inc. March, 2005.
- 7.Kovia (papain, urea) ointment US prescribing information. Stratus Pharmaceuticals Inc. December, 1999.
- 8.Panafil (papain, urea, chlorophylin copper complex sodium) ointment US prescribing information. Healthpoint, Ltd. December, 2004.
- 9.Panafil (papain, urea, chlorophylin copper complex sodium) ointment US prescribing information. Healthpoint, Ltd. March, 2004.
- 10.Ziox (papain, urea, chlorophylin copper complex sodium) ointment US prescribing information. Stratus Pharmaceuticals Inc. August, 2000.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.