Neuromuscular Blocking Agents/Trimethaphan Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are given together, the effects of one or both medicines may increase.
What might happen:
The effects of the nondepolarizing muscle relaxant will last for a longer time.
What you should do about this interaction:
The nondepolarizing muscle relaxant group of drugs is only used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all your healthcare professionals (e.g. doctors and pharmacists) are aware of all the different medicines that you are taking. This includes prescription and non-prescription medicines, herbal medicines, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Deacock AR, Davies TDW. The influence of certain ganglionic blocking agents on neuromuscular transmission. Br J Anaesth 1958;30:217-25.
- 2.Wilson SL, Miller RN, Wright C, Hasse D. Prolonged neuromuscular blockade associated with trimethaphan: a case report. Anesth Analg 1976 May-Jun; 55(3):353-6.
- 3.Nakamura K, Koide M, Imanaga T, Ogasawara H, Takahashi M, Yoshikawa M. Prolonged neuromuscular blockade following trimetaphan infusion. A case report and in vitro study of cholinesterase inhibition. Anaesthesia 1980 Dec;35(12):1202-7.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.