Apomorphine/Promethazine Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Apomorphine increases the activity of dopamine in the brain. Promethazine blocks the activity of dopamine in the brain.
What might happen:
Promethazine could counteract the beneficial effects of apomorphine, and apomorphine may not work as well. For example, your symptoms of Parkinson's disease could get worse.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you notice any changes in your symptoms.Your doctor may want to change or adjust the dose of your promethazine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Apokyn (apomorphine hydrochloride) US prescribing information. Tercica, Inc. May, 2019.
- 2.Oertel WH Berardelli A Bloem Br etal. Chapter 15 - Late (complicated) Parkinson's disease in European Handbook of Neurological Management. 2011; Volume 1, 2nd Edition:237 - 267.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.