Zolpidem/Ciprofloxacin Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Ciprofloxacin may slow down how quickly your liver processes your sleep medicine.
What might happen:
You may notice an increase in side effects such as confusion, memory loss, sleep-walking or daytime drowsiness.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Call you doctor as soon as possible if you have confusion/not thinking clearly, memory loss, daytime drowsiness, or have been told you were sleep-walking or doing other activities when you are asleep. Your doctor may want to change your sleeping pill or the dose of your sleeping pill. Use caution and know how these medicines affect you before driving or operating machinery.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Von Moltke LL, Greenblatt DJ, Granda BW, Duan SX, Grassi JM, Venkatakrishnan K, Harmatz JS, Shader RI. Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations. Br J Clin Pharmacol 1999 Jul;48(1):89-97.
- 2.This information is based on an extract from the Certara Drug Interaction Database (DIDB) Platform, Copyright Certara 1999-2023..
- 3.Ambien CR (zolpidem tartrate) US prescribing information. Sanofi-Aventis U.S. LLC August, 2019.
- 4.Cipro (ciprofloxacin hydrochloride) US prescribing information. Bayer Corporation March, 2022.
- 5.Ciprofloxacin Australian prescribing information. Aspen Pharmacare Ltd 23 June 2022.
- 6.Ciprofloxacin Canadian prescribing information. Teva Canada Limited March 23, 2022.
- 7.Ciprofloxacin UK prescribing information. Quattro Pharma Limited 24 November 2023.
- 8.Vlase L, Popa A, Neag M, Muntean D, Leucuta SE. Pharmacokinetic interaction between zolpidem and ciprofloxacin in healthy volunteers. Eur J Drug Metab Pharmacokinet 2011 Jan;35(3-4):83-7.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.