Reviewer: Cahira, 35-44 Female on Treatment for less than 1 month (Patient)

Comment:
Have been prescribed by gynecologist for pelvic unknown pain been on it for 2 weeks now and I feel terrible. Feel like I have a fever even though I don't, had several episodes of painful headaches, terrible nightmares can't sleep 8h in a row, nauseous can't eat at all for many days in a row now. Feel depressed like crying all the time for no reason, very on edge like I wanna kill som ... Show Full Comment

Comment:
Have been prescribed by gynecologist for pelvic unknown pain been on it for 2 weeks now and I feel terrible. Feel like I have a fever even though I don't, had several episodes of painful headaches, terrible nightmares can't sleep 8h in a row, nauseous can't eat at all for many days in a row now. Feel depressed like crying all the time for no reason, very on edge like I wanna kill someone or just lash out at my partner constantly for just being in the house and breathing This medication is really hard to take side effects are huge not sure if I'll stay on it very long and I should mention that I have panick/anxiety in my background but never depressed Side effects of this medicine are as bad as Paxil when I started it 15 years ago the first month was awful but my anxiety got better after the first month contrarily to Orillisa which has had no effect on my pelvic pain so far. Be really careful with depression and suicidal thoughts this medicine is definitely not for everybody and should carry the "black box" suicide warning box
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Reviewer: Caridad Precio, 25-34 on Treatment for 1 to 6 months (Patient)

Comment:
Orilissa is terrible. I've never felt such stabbing headaches in my entire 28 years of living. The night sweats and insomnia were FAR worse than the night sweats with Lupron. My skin color literally changed and I started to look pale yellow in a matter of minutes. My blood flow changed and it was quite obvious.. from the skin color change to just physically feeling a lot different overall. The ... Show Full Comment

Comment:
Orilissa is terrible. I've never felt such stabbing headaches in my entire 28 years of living. The night sweats and insomnia were FAR worse than the night sweats with Lupron. My skin color literally changed and I started to look pale yellow in a matter of minutes. My blood flow changed and it was quite obvious.. from the skin color change to just physically feeling a lot different overall. The only thing Orilissa does is stop some of the pain but overall I hate this medication. It's by far worse than taking opioids/NSAIDS as needed while still having a healthy monthly cycle. We seriously need better treatment options all together. Orilissa is dangerous and I would not recommend unless you're seriously ill
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Reviewer: LaurStevens, 25-34 on Treatment for 1 to 6 months (Patient)

Comment:
I was prescribed to take the twice daily 200mg dose of Orilissa to help with pain from endometriosis - pain with sex/orgasming, awful periods, cramping, lower back pain and IBS symptoms cause by endo. My insurance refused to cover the drug so I was being provided samples from my doctors office. My doctor started me on a one-month trial which actually went pretty well. , Besides a nonexistent sex ... Show Full Comment

Comment:
I was prescribed to take the twice daily 200mg dose of Orilissa to help with pain from endometriosis - pain with sex/orgasming, awful periods, cramping, lower back pain and IBS symptoms cause by endo. My insurance refused to cover the drug so I was being provided samples from my doctors office. My doctor started me on a one-month trial which actually went pretty well. , Besides a nonexistent sex drive and some vaginal dryness I had no other side effects. I continued to be on the Orilissa for six more weeks. Unfortunately my doctors office ran out of samples so I had to be off of it for two weeks. Once they got the samples back in I went on it for another three weeks and thatâ??s when things really got bad. On top of the lack of sex drive and vaginal dryness I had experience before, I started experiencing extreme mental fogginess, extreme depression and anxiety, hormonal mood swings, lack of appetite, nausea, more frequent IBS symptoms of constipation or diarrhea, and it was doing nothing for my endo pain. The last straw for me was when I started experiencing what I thought was appendix pain and then ended up being liver pain. My liver became extremely inflamed and swollen because of the drug and a blood test confirmed high levels of liver enzymes acting like my liver was trying to fight off the beginnings of liver disease. Because of this, it scared me enough to stop the taking Orilissa since my liver was struggling to process it. Iâ??m now treating my symptoms more holistically but having stage four endometriosis I most likely will end up having surgery.
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Reviewer: Rosie, 19-24 Female on Treatment for 1 to 6 months (Patient)

Comment:
Reading these comments just goes to show how differently everyone reacts to a medication. I have been on 200 mg of Orilissa twice daily for 3 months now. I have 3 more months, for a total of 6 months on the medication. The first couple months were brutal, as other people stated. I had horrible hot flashes, I could not sleep well, my joint pain was very uncomfortable, I had some nausea, and I would ... Show Full Comment

Comment:
Reading these comments just goes to show how differently everyone reacts to a medication. I have been on 200 mg of Orilissa twice daily for 3 months now. I have 3 more months, for a total of 6 months on the medication. The first couple months were brutal, as other people stated. I had horrible hot flashes, I could not sleep well, my joint pain was very uncomfortable, I had some nausea, and I would occasionally get a headache (taking advil helped). However, I have noticed a significant decline in these side effects after reaching my half way point. I can sleep so much better now, my body doesn't ache as badly, and I don't get as many hot flashes or nausea. As soon as I started the medication, I had no more periods, which has been AMAZING! I have been suffering from endometriosis since I was around 16 years old (I am 24 now). Everyday I would have lower abdominal pain, constant cramping, bloating, gas, painful bowel movements, painful sex, and heavy periods. I was on a birth control since high school, but it did not subside my pain at all. Before starting the medication, I had a laparoscopy performed and then my doctor started me on Orilissa to kill off any endometrial tissue that was left over that she could not get with the laser. So I'm not sure how well Orilissa works alone, but paired with my laparoscopy, the pain and discomfort I was feeling for years is COMPLETELY GONE! The side effects at the beginning have been well worth it for me. One complaint I have about the manufacturing of the drug is that it is very difficult to pop it out of the packet. I wish they would fix that because it hurts my thumbs! I never experienced any mood swings, no depression, and no increase in my anxiety. My side effects were more physical than mental. I did gain some weight unfortunately. So far it's been about 5 extra pounds, but I know once I get off the medication my metabolism will speed back up again. I also take 4 tablets of Citracal per day to help with my bones. Good luck!
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Reviewer: Courtney, 25-34 on Treatment for less than 1 month (Patient)

Comment:
Wow, where to begin. I started feeling side effects on day 1 of taking Orlissa. I was just so blank that day. Had a terrible headache. A few days in me and my husband had to actually make a plan for when i was home along so i wouldn't be alone. I had suicidal thoughts ( i do have a history of depression.) i couldn't focus on anything it felt like i had dementia. Blurry eye sight, i'm h ... Show Full Comment

Comment:
Wow, where to begin. I started feeling side effects on day 1 of taking Orlissa. I was just so blank that day. Had a terrible headache. A few days in me and my husband had to actually make a plan for when i was home along so i wouldn't be alone. I had suicidal thoughts ( i do have a history of depression.) i couldn't focus on anything it felt like i had dementia. Blurry eye sight, i'm holding onto water like crazy, i could hardly lift a gallon of milk my bones hurt so bad, can cry at anything. You name it i got it. I just stopped taking the medication per dr advise. I was warned that this can make your BC ineffective. I use the depo shot and never had any phantom period pain or bleeding. But with this i have all the pms symptoms too? I dont understand how this drug made it to the public. I feel worse with the Orlissa symptoms then i do with my everyday terrible pain. Even if this drug took care of my problem i would flush it down the toilet. It's not worth it.
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