Reviewer: 13-18 Female on Treatment for less than 1 month (Patient)

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Reviewer: GloriaPuppy, 13-18 Female on Treatment for less than 1 month (Patient)

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I have had constant migraines for six years and am never without headache pain. My neurologist suggested trying this and my family decided to give it a try. I am age 14, and this made my migraines worse not better. They also performed a lumbar puncture while I was in the hospital. It was negative and I am still in a lot of pain. My neurologist is out of ideas and seems to think it is all in my hea ... Show Full Comment

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I have had constant migraines for six years and am never without headache pain. My neurologist suggested trying this and my family decided to give it a try. I am age 14, and this made my migraines worse not better. They also performed a lumbar puncture while I was in the hospital. It was negative and I am still in a lot of pain. My neurologist is out of ideas and seems to think it is all in my head just because the treatment didn't work. I am very frustrated and am going to switch neurologists again. I have been researching why it might not have worked, and found that DHE isn't effective in people with hemiplegic and basilar migraines. I seem to have all the symptoms of hemiplegic migraines, so I am going to bring this to my new neurologist's attention. The side effects were bad with this drug, but barely tolerable. It is recommended for cluster headaches, so if you suffer from these, I would consider trying DHE.
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Reviewer: Honeygal1, 45-54 Female on Treatment for less than 1 month (Caregiver)

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DHE infusion makes my daughter's migraines WORSE! We tried it at her neurologist's office last summer, after high school ended, when she was 15. Hurt more (flared the pain), never helped, even days later. Then, in desperation in the midst of a 2 month massive migraine, we agreed to try a few days of DHE (and we assumed other) infusions in the hospital. They were supposed to do 1/4 dose ... Show Full Comment

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DHE infusion makes my daughter's migraines WORSE! We tried it at her neurologist's office last summer, after high school ended, when she was 15. Hurt more (flared the pain), never helped, even days later. Then, in desperation in the midst of a 2 month massive migraine, we agreed to try a few days of DHE (and we assumed other) infusions in the hospital. They were supposed to do 1/4 dose treatments of DHE instead of 1/2 dose (but moved up to 1/2 dose without telling us on the 4th treatment). And they were concerned about Medication Overuse Headache, so they wouldn't give her pain medicine either. The hospital wanted to try five 1/2 doses to be sure it didn't work. IT DIDN'T WORK! More wasn't better. They didn't have other things to try. Daughter was completely miserable and suffering. For you to know: DHE doesn't work for everyone. Also, DHE seems to mess with IVs, so the IVs need to be moved after a few infusions. The hospital visit was a completely terrible experience which our daughter will probably never fully get over.
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Reviewer: howsle, 25-34 Male on Treatment for 2 to less than 5 years (Patient)

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This medication is administered, usually inpatient, every 8 hrs for 2 to 5 days. It will cause GI upset in most individuals. For that reason, Reglan (metoclapromide) is administered. Reglan has been known to cause agitation and restlessness in some people. I found the regimen to reduce the intensity of my chronic migraine reliably.

Comment:
This medication is administered, usually inpatient, every 8 hrs for 2 to 5 days. It will cause GI upset in most individuals. For that reason, Reglan (metoclapromide) is administered. Reglan has been known to cause agitation and restlessness in some people. I found the regimen to reduce the intensity of my chronic migraine reliably.
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Reviewer: JLove, 55-64 Male on Treatment for less than 1 month (Caregiver)

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Just a note to some of the reviewers. My husband has chronic daily migraines (17 years). I noticed Reglan was used in conjunction with the DHE. He has Never had DHE, but the Reglan gave him the side-effect of wanting to run, "jump out of his skin," antsy feeling, etc. I was thinking maybe the Reglan or other meds given with the DHE may be causing the negative side-effects rather than ... Show Full Comment

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Just a note to some of the reviewers. My husband has chronic daily migraines (17 years). I noticed Reglan was used in conjunction with the DHE. He has Never had DHE, but the Reglan gave him the side-effect of wanting to run, "jump out of his skin," antsy feeling, etc. I was thinking maybe the Reglan or other meds given with the DHE may be causing the negative side-effects rather than the DHE itself. The Reglan really bothered him a lot. Also, OTC, Percocet (Narcotics) and Triptans (Imitrex, Relpax, Maxalt, etc) will cause MOH--Medication Overuse Headaches that are a daily occurrence & will not stop until the patient stops those types of meds. The DHE can be used to quickly stop the offending medications that cause "rebounding" headaches & then the person needs to use an appropriate Preventative like Elavil, Timolol or whatever ends up working the best for them & only use the other types of meds (Triptans/OTC/DHE injections) occasionally for breakthrough headaches. The main thing is to get off the MOH medications & to keep trying preventative medications until the patient finds the one or combination that works best for them. We will be trying I.V. DHE to break the "rebound" headaches, stop the addictive/rebounding medications & find preventatives that we hope will at least bring the pain down. We are nervous about side-effects of DHE, but we are running out of options. His head pain averages between an 8-9+ night & day. Hope this is helpful to someone--Please pray he will respond positively & get the right treatment.
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